A method of assessing the risk of rapid progression of chronic kidney disease in patients with pre-dialysis chronic kidney disease includes determining urinary uromodulin levels. Patients with pre-dialysis chronic kidney disease additionally have their urine albumin determined. The ratio of urinary albumin to urinary uromodulin is calculated. The results are compared with the glomerular filtration rate and comorbidity index of these patients. If the value of the urine albumin/uromodulin ratio is more than 5.24 μg/mL, then it is considered a high risk of rapid progression of chronic kidney disease.